The field of learning spaces research has generated considerable discussion in the academic community and prompted several institutions either to construct or plan to construct technology-enhanced learning environments. Despite the enthusiasm expressed for transforming formal learning spaces, there is a dearth of systematic, empirical research on these spaces on teaching and learning. In this presentation, we present results from a grant-funded mixed-methods research project that investigated the effects of innovative technology-enhanced classrooms on student learning at the University of Minnesota. Specifically, we provide evidence that space affects learning, how space affects learning, and how it matters to different student populations.